Long COVID Persistent complement dysregulation with signs of thromboinflammation in active Long Covid
'After discovering that the complement system is hyperactivated in people with persistent covid, researchers have wondered why it had been activated in the first place. This has led them to track more than 80,000 antibodies against viruses, since antibodies have the ability to activate the complement system. The results indicate how persistent covid could be treated by modulating the immune system'
The complement system: https://www.ncbi.nlm.nih.gov/books/NBK27100/
The abnormal activation of a part of the immune system, called the complement system, is at the origin of persistent covid, according to international research led by the University Hospital of Zurich. Research has identified biomarkers that can improve the diagnosis of the disease and pharmacological targets that can improve its treatment by modulating the immune system.
According to results presented today in the journal Science , deregulation of the complement system leads the immune system to attack cells of the endothelium, which is the inner wall of blood vessels. This inflames the endothelium and increases the tendency of the blood to form thrombi. In this process, the complement system itself is reactivated, thus creating a feedback loop that makes it difficult to resolve the disease. Immune proteins attack blood vessels, which feeds back into the immune reaction and makes healing more difficult.
“In light of our data, early cardiovascular evaluation of patients with persistent Covid should be considered,” the researchers write in Science .
Scroll down for related articles. https://www.science.org/doi/10.1126/science.adg7942
Immune modulators can stimulate the immune system. That can be a good or bad thing. (I have several autoimmune disorders so have to to be more careful, but COVID seems to be triggering them in previously healthy people. Don't be gobbling anything down without discussion with a doc)
Remember that Vitamin D is an immune modulator, so make sure to check your levels. This may also be why Kefir and other good bacteria seem to benefit long COVID sufferers as well. (I make my own kefir with crystals. Saves a ton of money and use it to make homemade cheese recipes, salad dressings and more) The list of other modulators is at the bottom. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC538513/
Well, my husband and I went to Puerto Vallarta last week, and had to stand in line for customs. My husband didn't mask and now he has covid. Got the Paxlovid and am hoping I am not next. Guess I will take a boatload of D and Zinc. We went 4 years without getting it, and he's ok,😷 but damn.