Long COVID Persistent complement dysregulation with signs of thromboinflammation in active Long Covid
'After discovering that the complement system is hyperactivated in people with persistent covid, researchers have wondered why it had been activated in the first place. This has led them to track more than 80,000 antibodies against viruses, since antibodies have the ability to activate the complement system. The results indicate how persistent covid could be treated by modulating the immune system'
The abnormal activation of a part of the immune system, called the complement system, is at the origin of persistent covid, according to international research led by the University Hospital of Zurich. Research has identified biomarkers that can improve the diagnosis of the disease and pharmacological targets that can improve its treatment by modulating the immune system.
According to results presented today in the journal Science , deregulation of the complement system leads the immune system to attack cells of the endothelium, which is the inner wall of blood vessels. This inflames the endothelium and increases the tendency of the blood to form thrombi. In this process, the complement system itself is reactivated, thus creating a feedback loop that makes it difficult to resolve the disease. Immune proteins attack blood vessels, which feeds back into the immune reaction and makes healing more difficult.
“In light of our data, early cardiovascular evaluation of patients with persistent Covid should be considered,” the researchers write in Science .
Immune modulators can stimulate the immune system. That can be a good or bad thing. (I have several autoimmune disorders so have to to be more careful, but COVID seems to be triggering them in previously healthy people. Don't be gobbling anything down without discussion with a doc)